This research aims at analyzing the Effect of Perceptions of Benefits, Ease of Use, and Security towards the Interest in Using DANA E-Wallet, both partially and simultaneously. The population in this research was all DANA e-wallet users in Semarang with a sample of 100 respondents using random sampling technique. The data used in this research are primary data obtained through interviews and questionnaires. The analytical model uses Multiple Linear Regression Model. Meanwhile, the data analysis techniques use Statistical Test t, Statistical Test F, and Coefficient of Determination Test (R²). The results of the analysis and discussion in this research show that each variable of perceptions of benefits, ease of use, and security partially has significant effects towards the interest in using DANA e-wallet. Simultaneously, the overall variables of perceptions of benefits, ease of use, and security have a significant effect towards the interest in using DANA e-wallet.