Profit is the difference between revenue (revenue) realization arising from transactions in a certain period with the costs incurred in that period. Profit growth is the difference in the amount of profit in the year concerned with the amount of the previous year's profit divided by the amount of profit in the previous year. Profit is important information in a financial statement. This figure is important for the calculation of taxes, serves as the basis for the imposition of taxes to be received by the state, to calculate dividends to be distributed to the owner and to be held in the company, a guide in determining investment policy and decision making, the basis for forecasting profit and economic events other companies in the future, serve as a basis for efficiency calculation and assessment, and to assess the performance or performance of the company, its segments, and divisions. This study aims to examine the effect of CAR, NPF, ROA, OER and FDR on profit growth in Sharia Commercial Banks in Indonesia. This study uses secondary data. The sampling technique used is purposive sampling with samples from 11 sharia banks for 5 years. The model used in this research is multiple regression analysis model. Data analysis techniques used include F test, R2 test, and t test. The results of this study indicate that NPF variables significantly influence profit growth, while CAR, ROA, OER and FDR have no significant effect on profit growth.