This research aims to analyze the effect of Capital Adequacy Ratio (CAR), Operating Efficiency Ratio (OER), Non Performing Financing (NPF) and the Financing to Deposit Ratio (FDR) partially and simultaneously toward profit growth in Sharia Banks in Indonesia in the Period of 2012-2016. The population in this research is all of Sharia Banks in Indonesia in the Period of 2012-2016. This research uses purposive sampling method. The amount of sample in this research is 8 (eight) Sharia Banks. The analysis model uses panel data regression model and analysis techniques to the hypothesis uses the t-test, F-test and R2 test. The result in this research is of Capital Adequacy Ratio (CAR), Operating Efficiency Ratio (OER) and Financing to Deposit Ratio (FDR) partially have significant effect to Profit Growth at Sharia Banks in Indonesia in the Period of 2012-2016. Non Performing Financing (NPF) partially has not significant effect to profit growth at Sharia Banks in Indonesia in the Period of 2012-2065. Simultaneously Capital Adequacy Ratio (CAR), Operating Efficiency Ratio (OER), Non Performing Financing (NPF) and the Financing to Deposit Ratio (FDR) have significant effect to profit growth at Sharia Banks in Indonesia in the Period of 2012-2016.